Biochemistry of Sporidesmin

D.E. Wright

Ruakura Agricultural Research Centre, Hamilton

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Proceedings of the New Zealand Society of Animal Production. 1969, 29: 132-136

The biosynthesis of sporidesmin labelled with carbon-14 from radio-active tryptophan, alanine, serine, glycine or methionine is reported. Sulphur-35 from labelled sulphate, methionine or cysteine is also incorporated into the toxin. A possible pathway for its biosynthesis is proposed.

The level of dietary protein influences the susceptibility of small animals to sporidesmin, the animals being more easily poisoned when fed a low-protein diet. The addition of casein, phosphopeptones prepared from casein, or synthetic DL-phosphoserine had a protective effect. Regression of the thymus gland in poisoned rats was observed, the extent of the regression being a measure of the severity of the illness.

Keywords: NZSAPAB;

Last Updated 24-08-2000