The Booroola F gene is excluded from close genetic linkage with
either the haemoglobin Beta or follicle stimulating hormone Beta loci
G.W. Montgomery, M.L. Tate, J.A. Sise, D.F. Hill
MAF Technology Molecular Biology Unit, Department of
Biochemistry, University of Otago, Dunedin
Proceedings of the New Zealand Society of Animal Production.
1990, 50: 411-416
Genetic variation in the beta chain of haemoglobin (HBB) and the
beta chain of follicle stimulating hormone (FSHB) was analysed for
linkage with the Booroola F gene in large half-sib families or a
backcross Romney x Booroola Merino flock where the Booroola F gene was
segregating. The half-sib families were highly informative at the HBB
locus with 6 of 7 sires heterozygous (AB) for the two alleles.
Recombination between the HBB and F gene loci were observed in all six
families and the F gene was significantly excluded from within 15
centimorgans (cM) of HBB. A cDNA probe for the FSHB gene detected an
insertion/deletion polymorphism close to exon 3 of the gene.
Recombination was observed in 4 pedigrees in the half-sib families and
the backcross flock and the F gene was excluded from within 5 cM of the
FSHB gene.
Keywords: NZSAPAB;
genetic linkage; recombination; Booroola F gene; haemoglobin;
FSH
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Last Updated 25-01-1997
