Cloning and characterization of the bovine myostatin promoter
M. Sharma, J.K. Martin, F. Jeanplong, M. Thomas, M.R. Spiller,
J.J. Bass and R. Kambadur
Animal Genomics, AgResearch, Hamilton, New Zealand.
Proceedings of the New Zealand Society of Animal Production.
2000, 60: 90-93
Myostatin a TGF beta superfamily member has been shown to be
present in high levels in the myogenic precursor cells of dermomyotome
and in the adult muscle fiber. To identify cis-acting DNA elements
involved in myostatin gene expression, we have isolated and sequenced
several kilobases of the bovine myostatin promoter region. Sequence
analysis of the 1.6 kb immediate upstream region of bovine myostatin
revealed several muscle specific transcription factor binding sites such
as E-boxes and an MEF2 binding site in this region.
Keywords: NZSAPAB;
Myostatin; promoter; Muscle specific transcription factor binding sites.
Last Updated 12-07-2000
